1. annoyance, botheration, irritation, vexation

the psychological state of being irritated or annoyed

• annoyance
• botheration
• vexation

2. irritation, pique, temper

a sudden outburst of anger

Example Sentences:
'his temper sparked like damp firewood'

• pique
• temper

3. irritation

(pathology) abnormal sensitivity to stimulation

Example Sentences:
'any food produced irritation of the stomach'

4. excitation, innervation, irritation

the neural or electrical arousal of an organ or muscle or gland

• excitation
• innervation

5. discomfort, irritation, soreness

an uncomfortable feeling of mental painfulness or distress

• discomfort
• soreness

6. aggravation, irritation, provocation

unfriendly behavior that causes anger or resentment

• aggravation
• provocation

7. annoyance, annoying, irritation, vexation

the act of troubling or annoying someone

• annoyance
• annoying
• vexation