1. (adjective) afflicted with or marked by anxious uneasiness or trouble or grief

• disquieted
• distressed
• upset
• worried

2. (adjective) emotionally unstable and having difficulty coping with personal relationships

• maladjusted

3. (adjective) affected with madness or insanity

• brainsick
• crazy
• demented
• mad
• sick
• unbalanced
• unhinged

1. (adjective) having the place or position changed

• disarranged

2. (adjective) afflicted with or marked by anxious uneasiness or trouble or grief

• troubled

3. (adjective) emotionally unstable and having difficulty coping with personal relationships

• neurotic
• psychoneurotic

4. (adjective) affected with madness or insanity

• insane

1. (adjective) affected with madness or insanity

• craze
• delirium
• frenzy
• fury
• hysteria
• craziness
• daftness
• flakiness
• dementedness
• dementia
• insaneness
• lunacy
• madness
• sick